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From 'Angel Dust':
As dangerous as rogue angels get. Isaak is a Cherubim, of the second circle of Heaven, the highest ranking angel to have escaped Heaven, as far as we know. The Cherubim are extremely powerful. Lucifer, was of their number, before the rebellion. Isaak may be just the key that Ash is looking for. He could be powerful enough to tear a hole in the fabric of the spiritual realm.